Secreated anosmin-1 enhances FGF activity by promoting FGF8-FGFR1 complex formation, whereas inhibits both BMP5 and WNT3A activities.
Also induces the mesenchymal cells to secrete FGF10, which acts through WNT3A to sustain the AER’s expression of FGF8.
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WNT3A = Acts as a middle man in the positive feedback loop between the AER and limb mesenchyme.
WNT3A |