The song's lyrics are believed to be directed towards long time nemesis Ja Rule, but 50 Cent disputed this himself in a MuchMusic interview, stating that the song was not directed against Ja Rule, "But Ja Rule is a wanksta".
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Stewie Griffin from Family Guy appeared in a short clip at the 20th annual MTV Video Music Awards insulting 50 Cent, which has become a viral video circulating on numerous online services.