He is best known for his role in Journey to the West and its sequel, The Gentle Crackdown (co-star with Halina Tam), Off Pedder and Some Day (co-star with Teresa Mo), Rosy Business and No Regrets (co-star with Sheren Tang).
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He has achieved much praise for his roles, especially in the TVB drama Rosy Business creating a big trend in Hong Kong in 2009.
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A Wicked Ghost III: The Possession is a 2002 Hong Kong horror film produced by Stanley Tong, directed by Hung Chung-hap and starring Gigi Lai, Cheung Tat-ming, Grace Lam, Yip Sai Wing, Wayne Lai, Patrick Keung, Jenny Yam and Joyce Han.
The awards include Best Drama, Best Actress (Sheren Tang), Best Actor (Wayne Lai), Best Supporting Actress (Susan Tse), My Favourite Male Character (Lai) and Most Improved Male Artiste (Ngo Ka-nin).
For the benefit of his son's future, Sheung's father Tse Chong-Tin (Ha Yu) has not only invited the intelligent Tai Tsung-Man (Wayne Lai) to be Sheung's assistant, but also found him four special bodyguards playfully named Chuk (Congee), Fun (Rice Noodle), Mein (Wheat Noodle), and Fan (Rice).
Visible Secret is a 2001 Hong Kong horror comedy film directed by Ann Hui, starring Eason Chan, Shu Qi, Anthony Wong, Sam Lee, James Wong, Wayne Lai, Kara Hui, Tony Liu and Cheung Tat-ming.