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2 unusual facts about William Ernest Castle


William Ernest Castle

Castle entered the senior class of Harvard University in 1892 and in 1893 took a second A.B. degree with honors.

When the Eugenics Record Office was founded in 1912, he served as a member of its scientific advisory board, and in 1916 he was one of the 10 founders of the scientific journal Genetics.


Lethal alleles

In 1910, William Ernest Castle and C. C. Little reaffirmed Cuénot's discovery of a lethal gene by proving that a quarter of the offspring from crosses between heterozygotes died during embryonic development, due to failure to implant in the uterine lining.


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