The Southampton title had previously been created for Charles FitzRoy, eldest natural son of Charles II and the Duchess of Cleveland and the elder brother of Henry FitzRoy, 1st Duke of Grafton, but had become extinct in 1774 on the death of his son William FitzRoy, 3rd Duke of Cleveland and 2nd Duke of Southampton, six years before the creation of the barony of Southampton.
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The dukedom became extinct upon his death, however it was revived for his grand-nephew William Vane, 1st Duke of Cleveland
He spent the winter and spring each year at Hyères because he and his wife both suffered from ill health.