The couple had 9 children: 6 sons, including Alexander Brown Mott (1826-1889), Valentine Mott, Jr. (1822-1854), and Thaddeus P. Mott; and 3 daughters, including Louisa Dunmore Mott, who in 1842 married the surgeon William Holme Van Buren.
President Abraham Lincoln offered to make Van Buren Surgeon General at the time of the war, and on his refusal consulted him with regard to the appointment.
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