In 1764, while living in or near London, Serle became a friend of William Romaine.
Subsequently Middleton had a succession of positions in London, where he was curate to William Romaine.
His maternal grandfather was William Romaine (1714–95), the famous eighteenth century pastor and evangelist, and the author of "The Life, Walk and Triumph of Faith".
He gained experience in London February 1772 and August 1775, influenced by William Romaine.
To evade the injunction she was compelled to take shelter under the Toleration Act placing her among the dissenters, and severed from the Connexion several eminent and useful members, among them William Romaine and Henry Venn.
Dodwell, like his father, was a keen controversialist: his opponents included Conyers Middleton, William Romaine, William Whiston, and others.
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