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In 1794, Lord Wynford married Mary Anne, daughter of Jerome Knapp Junior of Chilton in Berkshire (now Oxfordshire), Clerk of the Haberdashers' Company, by his second wife, Sarah, daughter and eventual heiress of George Noyes of Southcote, Berkshire, and Andover, Hampshire.
Wynford was the son of William Best, 1st Baron Wynford, Chief Justice of the Common Pleas and his wife, Mary Anne, daughter of Jerome Knapp Junior of Chilton in Berkshire (now Oxfordshire), Clerk of the Haberdashers' Company, by his second wife, Sarah, daughter and eventual heiress of George Noyes of Southcote, Berkshire & Andover.