In the latter game, which would be his last in the Major Leagues, he pitched a complete game, 7–2 victory over the Cincinnati Reds at Wrigley Field on September 22, 1966.
Several cultural references are made, including atheist Madalyn Murray O'Hair (the impossibility of her being ordained and becoming a priest) and Wrigley Field, which at the time was the only unlighted field in Major League Baseball.
In Texas, Cordero earned his first career MLB save on June 19, 2002, striking out all three batters he faced in the tenth inning in a 7–4 win over the Chicago Cubs at Wrigley Field.
On September 4, 2010, Mejia made his first major league start for the Mets at Wrigley Field against the Chicago Cubs.
On January 1, 2009, he scored the opening goal of the 2009 Winter Classic held at Wrigley Field against the Detroit Red Wings.
Playing for the Padres on September 2, 1972, against the Chicago Cubs at Wrigley Field, Stahl drew one of the most questionable bases on balls in baseball history — if only because of the circumstances surrounding it.
Outside from reporting, he was once a Wrigley Field usher, accordion player, and played in a band called "News Hole".
Foster was the home plate umpire for 300th career win of Tom Glavine, on August 5, 2007 at Wrigley Field.
The city is modeled after Chicago, including many of its landmarks, such as The 'L', Willis Tower (then known as Sears Tower), Wrigley Field, and Soldier Field.
Perhaps one of its most famous uses in the United States is the ivy covered brick outfield walls at Wrigley Field.
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During a Chicago Cubs-Cardinals game at Wrigley Field on July 19, 2004, pitcher Carlos Zambrano was ejected from the game for throwing at Edmonds.
In October 2009, the Ricketts family acquired a 95 percent controlling interest in Major League Baseball’s Chicago Cubs and Wrigley Field, as well as 20 percent of Comcast Sportsnet Chicago.
According to Warren Brown's history of the Cubs (written after the 1945 season, when Novikoff had been recently active with the team), Novikoff was afraid to approach the ivy on the Wrigley Field walls, fearing that it was poison ivy, thus diminishing his usefulness as an outfielder at the time, however Cubs trainer Bob Lewis took Novikoff to the vines one day and rubbed them all over his body and chewed some up proving they were safe.
In late 2007, Piniella appeared in a television commercial for Aquafina bottled water in which he parodies his famous June 2, 2007 meltdown at Wrigley Field.
The song that played most frequently on the Wrigley Field organ prior to a Grace at bat was "Taking Care of Business" which Grace explained was due to his bit part in a Jim Belushi film of the same name.
That August 7, in the second game of a doubleheader against the San Diego Padres at Wrigley Field, Kelleher, at 5-9 and 170 pounds, responded to Dave Kingman's hard slide into him on a double play attempt (Kingman was apparently angered over being hit by a Steve Renko pitch) by jumping on the 6-6, 210-pound Kingman's back and pummeling him with blows; the ensuing bench-clearing brawl resulted in the ejections of both players.
In the 2009 Under Armour All-America Game, played at Wrigley Field, he scored three runs, had four doubles and three RBIs, winning Most Valuable Player honors.
Players get to play in either a dome resembling the Tokyo Dome in Japan or Rogers Centre in Toronto, a contemporary baseball stadium (with homages to Japan's Koshien Stadium or Chicago's Wrigley Field), or in traditional-style stadium style (reminiscent of Chiba Marine Stadium in Japan or Busch Memorial Stadium in St. Louis).