X-Nico

unusual facts about XIAP


Yigong Shi

In 1995 when receiving his PhD degree in Biophysics from Johns Hopkins University, he has determined the crystal structure of several critical apoptotic proteins, including apaf-1, DIAP1, and the BIR3 domain of XIAP.


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XIAP |

Inhibitor of apoptosis

Later, five more human IAPs were discovered which included XIAP, c-IAPl, C-IAP2, NAIP,Livin and Survivin.

Activity of XIAP is blocked by binding to DIABLO (Smac) and HTRA2 (Omi) proteins released from mitochondria after pro-apoptic stimuli.


see also