In 1995 when receiving his PhD degree in Biophysics from Johns Hopkins University, he has determined the crystal structure of several critical apoptotic proteins, including apaf-1, DIAP1, and the BIR3 domain of XIAP.
XIAP |
Later, five more human IAPs were discovered which included XIAP, c-IAPl, C-IAP2, NAIP,Livin and Survivin.
•
Activity of XIAP is blocked by binding to DIABLO (Smac) and HTRA2 (Omi) proteins released from mitochondria after pro-apoptic stimuli.