Located just south of the city of Pittsburgh, the district lies between the Youghiogheny River and Monongahela River valleys in the southernmost region of Allegheny County.
By 1753, she and her band were living at the junction of the Monongahela and Youghiogheny Rivers near the present site of McKeesport, Pennsylvania.
In Chabon's 2000 Pulitzer Prize-winning novel The Amazing Adventures of Kavalier & Clay, an expert or experts on Yuggogheny cannibal cults are present at the party where Joe Kavalier saves Salvador Dalí from drowning.
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"Youghiogheny, Pennsylvania," is mentioned in a Rocky and Bullwinkle cartoon show, and the Youghiogheny is referred to as Yochio Geni in Thomas Pynchon's novel Mason & Dixon.
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The Youghiogheny River was likely the inspiration for the fictional Yuggogheny River, whose valley was used by Michael Chabon for the setting of his short story "In the Black Mill" from the 2000 collection Werewolves in their Youth.
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The Deep Creek Dam located about 8 miles north of Oakland, Maryland, consists of an earth and rockwall dam across a tributary of the Youghiogheny River that was completed in 1925 by the Pennsylvania Electric Company.
The lake was formed in 1944 by the damming of the Youghiogheny River upstream from Confluence, Pennsylvania.