Following the signing of the Oslo Accords between Israel and the Palestinian National Authority in 1993, which granted limited sovereignty to the Palestinians in parts of the West Bank and Gaza Strip, Khouri moved back to Palestine in order to establish business ventures there along with several other Palestinian entrepreneurs.
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He helped establish the Palestinian Development and Investment Company (PADICO), the largest Palestinian investment company, as well as the Palestinian National Beverage Company, which manufactures and markets Coca-Cola products under official franchise in the West Bank and Gaza Strip.