On the one hand, the central Valley of Oaxaca saw the development of the Zapotec culture, one of the most ancient and well known of the Mesoamerican region.
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There is evidence that a tzompantli-like structure has been excavated from the Proto-Classic Zapotec civilization at the La Coyotera, Oaxaca, site, dated from c.
In pre-Columbian Mexico many cultures matured into advanced civilizations such as the Olmec, the Toltec, the Teotihuacan, the Zapotec, the Maya and the Aztec before first contact with Europeans.