One of the few creatures that does feed on it is the nudibranch Okenia zoobotryon which is thought to live, feed and lay its eggs almost exclusively on the bryozoan and whose tissues then contain many of the same anti-predator chemicals.
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Zoobotryon verticillatum sometimes grows in association with the honeysuckle tunicate (Perophora viridis), the stolons of which intertwine with those of the bryozoan.