Prelabor rupture of membranes (PROM), or premature rupture of membranes, is a condition that occurs in pregnancy , and is defined as rupture of the membrane of the amniotic sac and chorion more than one hour before the onset of labor, which, in turn, is defined by the ACOG as uterine contractions of sufficient frequency and intensity to result in progressive effacement and dilation of the cervix.
However, in April 2004 Hargreaves's wife Christine sold the rights to the Mr. Men characters to the UK entertainment group Chorion, for £28 million.
Chorionic villi, found on the surface of the outermost membrane (the chorion) of the fetus