Inactivating mutations in SMARCB1, formerly known as hSNF5/INI1 and a component of the human SWI/SNF remodeling complex have been found in large number of rhabdoid tumors, commonly affecting pediatric population.
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There are at least five families of chromatin remodelers in eukaryotes : SWI/SNF, ISWI, NuRD/Mi-2/CHD, INO80 and SWR1 with first two remodelers being very well studied so far, especially in the yeast model.
An experimental pharmaceutical compound known as JQ1 blocks the region of BRDT responsible for chromatin remodeling, resulting in a temporary reduction of sperm production and quality; when tested in mice, the result was a cessation of male fertility that was reversed when use of JQ1 was discontinued.
Among the most frequently mutated genes are components of the SWI/SNF chromatin remodeling complex, which are lost in about 20% of tumors.