Wong Fei-hung, Clubfoot and "13th Aunt" cross the Pacific Ocean to America to visit Bucktooth So, who has opened a Po-chi-lam clinic there.
The film is set in 1900, during the late Qing Dynasty, when Wong Fei-hung and his companions (his new romantic interest 14th Aunt, his father Wong Kei-ying, and his students Leung Foon and Clubfoot) face new enemies.
According to an October 2008 press release by the Washington University School of Medicine, the gene is the first gene thought to be involved with clubfoot.