In the United States, two species are major pests of cucurbits, the striped cucumber beetle (Acalymma vittatum), which is mainly found east of the Mississippi River, and Acalymma trivittatum which is mostly found west of the Mississippi.
Similarly, cucurbit downy mildew (caused by Pseudoperonospora cubensis) is specific to cucurbits (e.g., cantaloupe (Cucumis melo), cucumber (Cucumis sativus), pumpkin, squash, watermelon (Citrullus lanatus) and other members of the Cucurbitaceae/gourd family).