In 1783, 79% of the Icelandic sheep stock were killed, probably as a result of fluorosis caused by the eruption of Lakagígar.
The second (c. 1933–45) focused on the relationship among fluoride concentrations, fluorosis, and tooth decay.
Hogenakkal Integrated Drinking Water Project is a fluorosis mitigation drinking water project being undertaken at Hogenakkal, Dharmapuri district, state of Tamil Nadu, India.
Local ground water in the area contains fluorine, and due to this contamination, consumption of the ground water causes fluorosis, a potentially debilitating disease affecting bones and joints.