Stimulation of pain fibers in a pattern consistent with that from inflammation switches on a form of amplification in the spinal cord, long term potentiation.
The oxidized metabolic products of linoleic acid, such as 9-hydroxyoctadecanoic acid and 13-hydroxyoctadecanoic acid, have also been shown to activate TRPV1, the capsaicin receptor, and through this might play a major role in hyperalgesia and allodynia.