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In addition to its use as a pharmaceutical medication, tofenacin is the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients.
Similarly, in September 2010, another study rebuffed the use of Venlafaxine and Duloxetine as first-line treatment in major depression, but recommend them as a second line option.
Non-psychotic major depressive disorder, in order to distinguish this condition from psychotic major depression (PMD)
Thus, intermittent depressive disorder, included in the Research Diagnostic Criteria (1975) was considered to identify minor versions of major depression ("minor depression") and not included in the DSM-III.