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That observation, called MHC restriction, led to a conundrum; namely, that the ability of a T cell to recognize foreign antigen also required that it recognize "self." With Paul M. Allen, Ph.D., the Robert L. Kroc Professor at Washington University School of Medicine, Unanue discovered that peptides from foreign antigens were bound to a group of molecules known as the major histocompatibility complex (MHC).
An international watershed in the publication and discussion of genetic evidence for ancient movements of people was that of Luigi Luca Cavalli-Sforza who used polymorphisms from proteins found within human blood (such as the ABO blood groups, Rhesus blood antigens, HLA loci, immunoglobulins, G-6-P-D isoenzymes, amongst others).
DPα and DPβ are encoded by two loci, HLA-DPA1 and HLA-DPB1, that are found in the MHC Class II (or HLA-D) region in the Human Leukocyte Antigen complex on human chromosome 6 (see protein boxes on right for links).
They and other CD1d-restricted T cells ('Type 2' NKT) recognize lipids and glycolipids presented by CD1d molecules, a member of the CD1 family of antigen presenting molecules, rather than peptide-MHC complexes.
Zinc finger, X-linked, duplicated family member C (ZXDC) is a human CIITA-binding protein involved in the activation of major histocompatibility complex (MHC) class I and II.