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The performance was Henley's final one on film, as he was diagnosed with manic depression shortly after completing his part and he retired from acting.
During an as-yet undiagnosed episode of manic depression (bipolarism) in 1996, actress Margot Kidder attempted to walk 12 miles from downtown Los Angeles to the La Crescenta home of her friend, writer Rosie Shuster.
In the Best Interest of the Children is a fact-based TV film starring Sarah Jessica Parker who plays a woman struggling with manic-depression while raising her five children.
She remained in the cast until December 2007, when she began rehearsals for the role of Natalie, the angsty teenage daughter of a woman with manic-depression in the musical "Next To Normal".
Dr John Frederick Joseph Cade AO (18 January 1912 – 16 November 1980) was an Australian psychiatrist credited with discovering (in 1948) the effects of lithium carbonate as a mood stabilizer in the treatment of bipolar disorder (then known as manic depression).