He prescribed huge doses of Methotrexate, a powerful drug, and in eight months, every trace of her cancer was reportedly eradicated.
Steroids are often used in the treatment of AIED, as well as cytotoxic agents such as Cyclophosphamide and Methotrexate.
Immunosuppressive drugs such as the therapeutic monoclonal antibody Daclizumab, Cyclosporine and Methotrexate have proven to be effective treatment options for birdshot chorioretinopathy.
This, and another antifolate drug, Methotrexate used by Dr. Farber were discovered and supplied by Dr. Yellapragada Subbarao Director, Research at Lederle Co. at Pearl River, NY.
Methotrexate was developed as a less-toxic alternative to aminopterin by Yellapragada Subbarao in 1946 and tested on 16 children by Sidney Farber and his colleague, Louis K. Diamond.
In a tofacitinib monotherapy study, the ACR score improved by at least 20% (ACR-20) in 67% of patients versus 25% who received placebo; and a study that combined the drug with methotrexate achieved ACR-20 in 59% of patients versus 35% who received methotrexate alone.