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Dinitrogen tetroxide, N2O4, an unstable dimer of nitric oxide;
The study demonstrated that GAPDH is S-nitrosylated by NO in response to cell stress, which causes it to bind to the protein SIAH1, a ubiquitin ligase.
In migraine, stimulation of the trigeminal nerve causes neurogenic inflammation via release of neuropeptides including Substance P, nitric oxide, vasoactive intestinal polypeptide, 5-HT, Neurokinin A and CGRP.
Louis Ignarro, co-recipient of the 1998 Nobel Prize in Physiology or Medicine for demonstrating the signalling properties of nitric oxide, is a member of the scientific committee of the company and Bengt Samuelsson, Nobel laureate 1982 serves as director on the company board.
Reactive nitrogen species (RNS) are a family of antimicrobial molecules derived from nitric oxide (·NO) and superoxide (O2·−) produced via the enzymatic activity of inducible nitric oxide synthase 2 (NOS2) and NADPH oxidase respectively.
He gained notoriety for his discoveries related to nitric oxide function and metabolism, and his exclusion from the 1996 Lasker Award and the 1998 Nobel Prize in medicine was strongly polemic.
Endothelin, and angiotensin are the vasocontrictors of smooth muscles while nitric oxide and prostacyclin are vasodilators of the smooth muscles.
A protein from Cryptococcus neoformans (Filobasidiella neoformans) that contains haemerythrin/HHE cation-binding domains is also involved in nitric oxide response.
He completed a project about the impact of inhaled nitric oxide on cerebral Malaria in Ugandan Children.