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In 1999, under the new joint editorship of Martin Kreitman (the current editor-in-chief), Takashi Gojobori, and Giorgio Bernardi, the journal made explicit its focus on "the fundamental issues in molecular evolution", to the exclusion of molecular phylogenetics (the purview of several other molecular evolution journals, most significantly Molecular Phylogenetics and Evolution) and origin of life research, except in cases that have "a special significance and impact".
In 1955 he published "Information, Reproduction and the Origin of Life," in American Scientist.