In 1999, under the new joint editorship of Martin Kreitman (the current editor-in-chief), Takashi Gojobori, and Giorgio Bernardi, the journal made explicit its focus on "the fundamental issues in molecular evolution", to the exclusion of molecular phylogenetics (the purview of several other molecular evolution journals, most significantly Molecular Phylogenetics and Evolution) and origin of life research, except in cases that have "a special significance and impact".
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In 1971, he became the initial editor of the Journal of Molecular Evolution, and in the late 1970s became President of the Linus Pauling Institute (then in 1992 of its successor, the Institute of Molecular Medical Sciences).
She taught physiology and biophysics for 13 years, while becoming affiliated with the National Biomedical Research Foundation, a Fellow of the American Association for the Advancement of Science, a councillor of the International Society for the Study of the Origins of Life (1980) and acting on the editorial boards of DNA, Journal of Molecular Evolution and Computers in Biology and Medicine.