On account of its relation to the MDxx chemical class, MDP2P, as well as safrole and isosafrole, are in the United States (U.S.) Drug Enforcement Administration (DEA) List I of Chemicals of the Controlled Substances Act (CSA) via the Chemical Diversion and Trafficking Act (CDTA).
The tree is of special concern, as it is being harvested at a high rate to obtain safrole, a precursor to the pesticide synergist piperonyl butoxide, the flavorant and fragrance piperonal, and the psychoactive drug MDMA.