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They show a high toxicity against Spodoptera litura larvae by inhibiting sodium channels, leading to strong paralytic activity and eventually to the death of the insect.
In both cases, these changes in excitability are typically due to mutation of the sodium channel •
Primary erythromelalgia is caused by mutation of the voltage-gated sodium channel α-subunit gene SCN9A.
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There are 10 known mutations in the voltage-gated sodium channel α-subunit NaV1.7 encoding gene, SCN9A.
A recent study revealed dysfunction of a particular sodium channel (Nav1.7) in a significant portion of the patient population with an idiopathic small fiber neuropathy.