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On April 1, 1758, a brief was obtained from the aged Pope Benedict XIV, appointing Saldanha, recommended by the Marquis of Pombal, to investigate allegations against the Jesuits that had been raised in the name of the Joseph I of Portugal.
When his career as professor was abruptly brought to an end by the suppression of the Jesuits in 1773, he followed an invitation of the abbot of the Cistercians of Salem Abbey to continue his literary activity in the monastery.
The Bourbon Kings espoused their relative's quarrel, seized Avignon, Benevento and Pontecorvo, and united in a peremptory demand for the total suppression of the Jesuits (January 1769).