Studies have shown that they have a mutualistic relationship with Chlorogonium alga, which makes tadpoles develop faster than normal.
Upon original release, Bakery Records included a copy of Tadpoles Destroy Terrastock - Live with all mail-orders for Smoke Ghost.
It has been shown, by scientists from the University of Warwick, that E-NTPDase2 stimulates the growth of the eye: by testing the enzyme on tadpoles, the tadpoles were found to develop extra eyes on their body.
It is especially popular among aquarists raising fry (baby fish) and tadpoles, to protect them from cannibalistic adults.
A striking parallel can be seen in the frog family Leptodactylidae, which has a very diverse reproductive system, including foam nests, non-feeding terrestrial tadpoles and direct development.
R. sirensis is kept as a pet by herpetoculturists and is considered to be one of the more difficult poison dart frogs to keep due to its relative rarity and the delicate nature of its tadpoles.