The film focuses on Matt Stutzman, an armless American archer; Norwegian table tennis player Aida Dahlen; the Rwandan sitting volleyball team; one-legged German swimmer Christiane Reppe and the tetraplegic Greek boccia player Greg Polychronidis.
Tetraplegic forensics expert Lincoln Rhyme (Denzel Washington) and a patrol cop, Amelia Donaghy (Angelina Jolie), team up to solve a string of murders all connected to a serial killer by his signature: a single shard of bone is removed from each of the victims.