The Staleys, who moved from Decatur, Illinois, to Chicago before the season, were named the APFA Champions over the Buffalo All-Americans.
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The Chicago Staleys (to be renamed the Chicago Bears after the end of the season), led by wide receiver George Halas, and the Buffalo All-Americans, led by quarterback Tommy Hughitt, were the two top teams in the league; each playing all of their games at home, Buffalo and Chicago amassed 6–0 records in league play.
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At one point, the Professional Football Researchers Association recognized a team by the name of the Syracuse Pros as joining and leaving the league in 1921, but the league has not recognized the claim, and the PFRA has backed off its assertion in more recent years.
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