Due to the 2011 Copa América, at the end of the 2011 Torneo Descentralizado's first round, the Torneo Intermedio will be played, with the participation of the 16 teams of the Primera División, 5 teams of the Segunda División, and 14 teams of the Copa Perú.
Luiz was present in every squad of new manager Mano Menezes and was called up for the 2011 Copa América, but did not make a single appearance at the tournament due to injury.
He has since participated in two major tournaments, the 2010 FIFA World Cup and the 2011 Copa América.
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Alcaraz was again first-choice for Paraguay during the 2011 Copa América, held in Argentina.
On 19 July 2011, Galatasaray officially announced the signing of Fernando Muslera from Lazio on a 5-year contract while he was on duty in the Copa América with Uruguay.
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Muslera was called again by coach Óscar Tabárez to represent Uruguay as the first choice goalkeeper at the 2011 Copa América, which was held in Argentina.
He has also been called up with the Mexico national team and the national under-23 team, playing in the 2011 Copa América, the 2011 Pan American Games, and the 2012 Summer Olympics.
In the 2011 Copa América in Argentina, he helped the Vinotinto finish a best-ever fourth in the continental competition, scoring in the last match, a 1–4 loss against Peru, in what was his 100th international cap.
Silva was also Uruguay's third choice goalkeeper in the 2010 FIFA World Cup and the 2011 Copa América.
Pereira was again an undisputed starter for Uruguay in the 2011 Copa América held in Argentina, with the national team winning its 15th continental tournament.
In June 2011, Ruidíaz was called up by the coach Sergio Markarián to the Copa América held in Argentina, being member of the squad that finished in the tournament's third place, after of the 4–1 victory over Venezuela, playing one game for the contest against the Chilean football team.
He was selected for Paraguay senior squad for the 2011 Copa América.
Following the retirement of fellow countryman Carlos Eugênio Simon he finally secured his maiden Copa América appointment in 2011, where he went on to officiate the final between Uruguay and Paraguay.