As a film editor, he is best known for collaborations with film director Spike Lee, editing some of Lee's best known films including Do the Right Thing (1989), Malcolm X (1992), He Got Game (1998), 25th Hour (2002) and Inside Man (2006).
However, Seven HD became the first Free-to-air commercial television channel introduced to metropolitan areas since 1988, when it launched prior on 15 October 2007, with 25th Hour being the first program broadcast at 10:30pm.
Siragusa also played a Ukrainian mobster in the movie 25th Hour.
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During this period he first worked with frequent collaborator Darren Aronofsky (Requiem for a Dream, The Fountain) in addition to other directors in the New York independent film world including: Todd Solondz (Storytelling), Paul Schrader (Autofocus) and Spike Lee (25th Hour).