Gwytherin is the setting for much of the action in the novel A Morbid Taste for Bones, first published in 1977 by Ellis Peters.
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The moving of Winifred's bones to Shrewsbury is fictionalized in A Morbid Taste for Bones, the first of Ellis Peters' Brother Cadfael novels, with the plot twist that her bones are secretly left in Wales, and someone else is put into the shrine.