In 1815 Humphry Davy publishes Elements of agricultural chemistry, possibly one of the first scientific studies on the subject.
An agricultural chemist, he was responsible for securing Penn State's designation in 1863 as a land-grant institution under the Morrill Land Grant Act.
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After much difficulty George Chapman Caldwell was recruited in 1867 as Professor of Chemistry(Agricultural Chemistry).
From 1871 he worked in the laboratory of agricultural chemistry at the Ecole d'agriculture in Grignon.