Confirmation of ion channels came with the development of the patch clamp leading to a Nobel prize in 1991 for Erwin Neher and Bert Sakmann.
In their Nobel Prize-winning work uncovering ionic mechanism of action potentials, Alan Hodgkin and Andrew Huxley performed experiments on the squid giant axon.
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The system, known as TR3548, was devised by a team led by Dr Philip Dee and designed under the aegis of chief designer Dr Alan Hodgkin, after receiving a request from the Air Ministry for such a system in early 1943.