They also fled to south-eastern Europe where they were granted safety and formed flourishing local Jewish communities, the largest being those of Salonika, Istanbul, and Sarajevo.
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From 1492, the year in which the Alhambra Decree issued mandating the expulsion of all Jews from Spain, until 1622, when it resurfaced in the Palace of Liria owned by the House of Alba, the whereabouts of the Alba Bible were unknown.
After the expulsion of the Jews from Spain in 1492, the building was devoted to various functions including a Hydrophobic hospital, a chapel for shoemakers and nursery school.
The family left Spain in 1492, settling in France, the Netherlands and Italy, after the Alhambra Decree expelled Jews and Muslims from Spain, not long after the beginning of the Spanish Inquisition.
The Ottomans had a benevolent attitude towards the Jews, having welcomed thousands of Jewish refugees who had recently been expelled from Spain by Ferdinand II of Aragon and Isabella I of Castile in 1492.