After Prince Henry's death Winniffe became chaplain to Prince Charles, but on 7 April 1622, when the Spaniards were overrunning the Electorate of the Palatinate, he gave offence by a sermon denouncing Gondomar, and comparing Spinola with the devil.
In 1622 the Spaniard Ambrogio Spinola constructed a fortification with seven bastions around Zandvliet, to strengthen the defenses of Antwerp against the northern Netherlands.
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In 1614 he had some share in the operations connected with the settlement of Cleves and Jülich.
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Several of Federico's galleys were destroyed by English war-ships on his way up the Channel.
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On the outbreak of the Thirty Years' War he made a vigorous campaign in the Lower Palatinate which included the sacking of many towns and villages, including Drais, and was rewarded by the grade of Captain-General.
He was the son of Ambrogio Spinola, 1st Marquis of the Balbases, (Genoa, Italy, 1569 - 25 September 1630), 1st duke of Sesto, (title awarded in Naples on 2 April 1612), granted the Grandee of Spain on 17 December 1621 with his marquisate, Conqueror of Breda, 1623, Governor of the Duchy of Milan, also a Knight of the Order of the Golden Fleece, 1631, and Giovanetta Bacciadone y Doria (1597–1615).
Pompeo Giustiniani (1569–1616), a native of Corsica, who served in the Low Countries under Alessandro Farnese and Ambrogio Spinola, 1st Marquis of the Balbases, where he lost an arm, and, from the artificial substitute which he wore, came to be known by the sobriquet Bras de Fer.