But when the Aetolians realised that Rome was to rule the Greek cities and asked Antiochus III the Great of Syria for help, the Roman general Manius Acilius Glabrio seized Lamia and advanced to Amfissa, where he conquered the Crissaean plain and besieged the town in 190 BC.
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In 426 BC, Spartan general Eurylochus, on his way to Naupactus, arrived to Delphi and sent a herald to Amfissa, in order to detach them from Athens and make the Amfissians leave him pass through their lands.
Desfina is built amphitheatrically and is located about 200 kilometres of Athens, roughly 35 kilometres of Livadia, 16 kilometres of Antikyra, 30 kilometres of Amfissa, 18 kilometres of Itea and roughly 30 kilometres of Delphi and Arachova.