To overcome his failure to secure gains against the Serbians, Andronikos III attempted to annex Bulgarian Thrace, but the new tsar Ivan Alexander of Bulgaria defeated Byzantine forces at Battle of Rusokastro on 18 July 1332.
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The Byzantine Emperor Andronikos II Palaiologos had Isaias confined to the monastery section of the Magnaura school in Constantinople in 1327, possibly due to the Patriarch's support for the emperor's grandson, Andronikos III Palaiologos during the civil war of 1321–1328.
Irene Palaiologina of Trebizond, illegitimate daughter of Andronikos III Palaiologos, reigning Empress of Trebizond in 1340–41