Tofisopam (Emandaxin and Grandaxin) is a drug that is a benzodiazepine derivative.
Anxiolytic medications that act as 5-HT receptor agonists (in particular, 5-HT1A) together with CRH and/or cortisol antagonists (which are implicated in the stress response) are hypothesized to be an appropriate method of achieving this therapeutic response.
In agitated patients or those with suicidal thoughts additive sedative/anxiolytic treatment is usually indicated.