On the ground floor of the museum are artifacts from ancient Amphipolis including a marble bust of a woman (4th century BC), a marble grave stela of an ephebe (5th century BC), a large gold finger ring and a gold olive wreath that were found in Macedonian Tomb 1 (3rd century BC), a headless marble statue of a woman wearing a peplos (1st century BC), and a portrait bust of the Roman empress Agrippina.
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On the first floor of the museum are items from the wider region of Thrace, from Galypsos, Oisyme, ancient Topeiros and Tragilos, Abdera and Mesembria.
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The museum contains prehistoric artifacts found all over the Kavala regional unit such as in Neapolis (old Kavala), Amphipolis and places such as Oisyme, Galypsos, Dikili Tas, Tragilos, Mesembria, Nikisiani and Avdira.
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