Advised by John Wheeler, his 1949 Princeton doctoral dissertation was entitled The Moderation and Absorption of Negative Pions in Hydrogen.
Since the 1960s, following the work of Arthur Wightman and Rudolf Haag, also modern quantum field theory can be considered close to an axiomatic description.
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R. F. Streater and A. S. Wightman, PCT, Spin and Statistics and All That, Princeton University Press, Landmarks in Mathematics and Physics, 2000.