The drug causes hepatocellular injury, generally shown by more frequent 3-fold or greater elevations above the upper limits of normal (ULN) of ALT or AST than the (nonhepatotoxic) control agent or placebo.
Alanine transaminase | GABA transaminase | aspartate | Aspartate transaminase | Aspartate-semialdehyde dehydrogenase |