Signals are often transmitted over balanced connections using the differential mode, meaning the wires carry signals of opposite polarity to each other (for instance, in an XLR connector, pin 2 carries the signal with normal polarity, and pin 3 carries an inverted version of the same signal).
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If a stereophonic or other binaural signal is plugged into such a jack, one channel (usually the right) will be subtracted from the other (usually the left), leaving an unlistenable L − R (left minus right) signal instead of normal monophonic L + R. Reversing the polarity at any other point in a balanced audio system will also result in this effect at some point when it is later mixed-down with its other channel.
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