Like her contemporary, Jacqui Morgan, she briefly worked in textile design after graduating from Pratt, then decided to turn her efforts towards illustration work.
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Nessim's childhood ambition was to be an artist, but it was only after befriending Robert Weaver and receiving encouragement to enter the New York Society of Illustrators show in 1960 that she became a professional artist.
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She was also the founder of the arts organization "The Fight Censorship Group", whose other members included Hannah Wilke, Louise Bourgeois, Judith Bernstein, Martha Edelheit, Eunice Golden, Juanita McNeely, Barbara Nessim, Anne Sharpe and Joan Semmel.