It runs through the border of the City of Manila with Quezon City and Caloocan from Rizal Avenue in Santa Cruz district to Gregorio Tuazon Street (formerly Calle Balic Balic) in Sampaloc district.
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It is located at the corner of Old Antipolo Street and Rizal Avenue in Sampaloc, Manila and derives its name from nearby Blumentritt Road, which is named after the Czech professor Ferdinand Blumentritt, friend of José Rizal and sympathizer of the Filipino cause.