BMP2 downregulates multiple mIRs, of which one, miR-133, directly inhibits Runx2, an early BMP response gene essential for bone formation.
It induces human osteoblast differentiation through bone morphogenetic protein-2/extracellular signal-regulated kinase 1/2 pathway.
In 2011, he gained public prominence for his research that uncovered the harmful side effects of Bone morphogenetic protein 2 therapy.
protein | Protein subunit | Protein-protein interaction | Krayzie Bone | Layzie Bone | Hfq protein | protein domain | Protein-protein_interaction | bone | Winter's Bone | Protein Data Bank | Bone Thugs-N-Harmony | Wish Bone | T-Bone Walker | RNA-binding protein | Orchestra of Skin and Bone | Bone Sharps, Cowboys, and Thunder Lizards | Bone | Promyelocytic leukemia protein | Paget's disease of bone | G protein | Flesh-n-Bone | Bone Thugs-n-Harmony | Wiskott–Aldrich syndrome protein | Protein G | protein dimer | Protein A | Philip J. Bone | Muirhead Bone | Journal of Bone and Joint Surgery |